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Russel’s teapot, or would serology suitable for historical reconstructions of COVID-19?

Author admin Posted on 8 December, 202024 June, 2022Tags , ,

“SARS–CoV–2 was circulating outside of China back in 2019”. Sounds familiar? One of most recent claims of this sort came about three weeks ago from Italy. A joined team of Istituto Nazionale Tumori (Milan), University of Siena, and a company VisMederi Srl re-analyzed blood samples spared from a cancer related project with around 1000 participants. Apolone and co-authors reported that up to 15% of the samples might had contained antibodies to the receptor-binding domain (RBD) of SARS-CoV-2 already by September … Continue reading “Russel’s teapot, or would serology suitable for historical reconstructions of COVID-19?”

Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis

Author admin Posted on 8 April, 20208 March, 2024   Leave a comment on Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis

In order to identify pathways related to the early development of rheumatoid arthritis (RA), we analyzed plasma samples from pre-symptomatic individuals, early RA patients, and 74 matched controls. The levels of proteins related to autoimmunity were measured using 153 antibodies. The data were analyzed using multifactorial linear regression model, random forest, and network enrichment analysis (NEA). There was a high agreement between the different statistical methods to identify the most significant proteins. The adipogenesis and interferon alpha response hallmarks differentiated … Continue reading “Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis”